Salarius Pharmaceuticals and Nationwide Children’s Hospital Disclose Research Findings from Presentation at 2021 AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics
The presentation, titled Targeting LSD1 protein scaffolding function in FET-rearranged sarcomas with SP-2577, disclosed preclinical research that demonstrated seclidemstat (SP-2577), Salarius’ lead drug candidate, has a differentiated mechanism of action that gives it potent activity in sarcomas compared to another LSD1 inhibitor. Previously published third-party research has revealed that LSD1 is highly expressed in various sarcoma subtypes, though not all LSD1 inhibitors show anti-tumor activity in these cancer types due to their respective mechanisms of action.
Salarius and Nationwide studied this concept by comparing seclidemstat, SP-2513 (an inactive control), and OG-L002 (representative compound of irreversible LSD1 inhibitors) in FET-rearranged sarcoma cell lines, specifically Ewing sarcoma, myxoid liposarcoma (MLS), desmoplastic small round cell tumor (DSRCT), and clear cell sarcoma (CCS). Highlights from the presentation included:
- Seclidemstat demonstrated potent activity across cell lines in vitro, while SP-2513 and OG-L002 had no/minimal activity against these cell lines.
- Preliminary in vivo assessment of seclidemstat efficacy in DSRCT patient-derived xenograft organoids resulted in a significant delay in time to event.
- Data indicates that the robust scaffolding inhibition function of seclidemstat is essential for reducing FET-rearranged driven sarcoma cell viability.
The presented preclinical data, in combination with results from the ongoing dose-expansion Phase 1/2 trial of seclidemstat in select sarcoma patients, demonstrate that seclidemstat’s differentiated mechanism of action gives it unique anti-cancer activity in FET-rearranged sarcomas compared to other LSD1 inhibitors. Ongoing research will focus on identifying potential biomarkers for selecting patients with increased sensitivity to seclidemstat.
“We are excited to have the opportunity to present the preclinical data that strongly supports the potential for seclidemstat in FET-rearranged sarcomas,” stated
The full poster presentation is available on the AACR website at https://www.aacr.org/meeting/aacr-nci-eortc-international-conference-on-molecular-targets-and-cancer-therapeutics/ .
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This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this press release are forward-looking statements. These forward-looking statements may be identified by terms such as “anticipate,” “potential,” “progress,” “design,” “estimate,” “continue,” “will,” “aim,” “can,” “believe,” “plan,” “allow,” “expect,” “intend,” “goal,” “provide,” “able to,” “position,” “project,” “developing,” “look forward,” “promising,” and similar terms or expressions or the negative thereof. Examples of such statements include, but are not limited to, statements relating to the following: Salarius’ growth strategy; the value of seclidemstat as a potential treatment for Ewing sarcoma, FET-rearranged sarcomas and other cancers; the nature of research related to patients with sensitivity to seclidemstat; Salarius’ differential therapeutic activity in several cancer types; Salarius’ development of seclidemstat for several cancers with high unmet medical need; bringing new therapies to market; and Salarius’ plans to initiate additional clinical trials. Salarius may not actually achieve the plans, carry out the intentions or meet the expectations or objectives disclosed in the forward-looking statements. You should not place undue reliance on these forward-looking statements. These statements are subject to risks and uncertainties which could cause actual results and performance to differ materially from those discussed in the forward-looking statements. These risks and uncertainties include, but are not limited to, the following: the sufficiency of Salarius’ capital resources; the ability of, and need for, Salarius to raise additional capital to meet Salarius’ business operational needs and to achieve its business objectives and strategy; Salarius’ ability to project future capital needs and cash utilization and timing and accuracy thereof; the ability of Salarius to access the remaining funding available under the CPRIT grant; future clinical trial results and impact of results on Salarius; that the results of studies and clinical trials may not be predictive of future clinical trial results; the sufficiency of Salarius’ intellectual property protection; risks related to the drug development and the regulatory approval process; the competitive landscape and other industry-related risks; market conditions and regulatory or contractual restrictions which may impact the ability of Salarius to raise additional capital; the possibility of unexpected expenses or other uses of Salarius’ cash resources; risks related to the COVID-19 outbreak; and other risks described in Salarius’ filings with the
Source: Salarius Pharmaceuticals, Inc.