Salarius Announces Publication of Scientific Paper Highlighting Potential of Combining Seclidemstat with Checkpoint Inhibitors
Seclidemstat Modulates Tumor Microenvironment to Help Genetically Mutated Cancer Types Overcome Resistance to Checkpoint Inhibitors in Preclinical Study
Data Supports Continued Study of Seclidemstat with Checkpoint Inhibitors
Dr. Sharma’s group used 3-D in vitro organoids to investigate the ability of Seclidemstat, a potent reversible inhibitor of the LSD1 enzyme, to promote anti-tumor immunity and T-cell infiltration in two types of ovarian cancer – small cell carcinoma of the ovary hypercalcemic type (SCCOHT) and ovarian clear cell carcinoma (OCCC) -- that both carry mutations in proteins of the SWI/SNF complex. The SWI/SNF complex plays an important role in modulating gene expression, and when proteins of the complex are mutated, it can result in cancer growth and progression. Mutations in the SWI/SNF complex occur in roughly 20% of human cancers, including ovarian cancer, which is one of the most lethal cancers affecting women.
Checkpoint inhibitors are designed to unleash an immune attack on cancer cells. However, checkpoint inhibitor therapies do not work in about 70% of cancer patients, and even patients who do show an initial response, many suffer a return of the disease. In this study, Seclidemstat modulated the tumor microenvironment to help overcome the resistance to checkpoint inhibitors.
“Dr. Sharma’s research represents a significant potential advancement for Salarius and Seclidemstat as it demonstrates the potential for the drug to be utilized in combination with checkpoint inhibitors in the treatment of a readily identifiable patient population with specific mutations,” stated
Dr. Sharma commented, “Transcriptome analysis of SCCOHT cell lines show that LSD1 is a highly expressed gene in tumors with SWI/SNF mutations which makes tumors with SWI/SNF mutations attractive tumor types for an LSD1 inhibitor. In addition, our data shows that Seclidemstat stimulates interferon pathways that cause an increase in cytokines and T-cell recruitment, which has a pronounced effect on cancers with these very mutations. Seclidemstat could be effective in patients with SWI/SNF mutations.”
A renowned cancer researcher, Dr. Sharma has led significant research with anti-cancer agents and co-founded several biopharmaceutical startups, including Salarius. During his time as a researcher at the University of Utah’s
More information on this research paper, is available at the link: https://www.biorxiv.org/content/10.1101/2020.01.10.902528v1
1 Raffaella Soldi,
Seclidemstat is a first-in-class, oral, small molecule designed for the reversible and noncompetitive inhibition of the LSD1 enzyme. Seclidemstat is based on the research of Dr. Sunil Sharma, Salarius’ co-founder, into LDS1 inhibition during his tenure at the University of Utah’s Huntsman Cancer Institute. As a reversible inhibitor, Seclidemstat could offer more efficacy, more flexible dosing and less toxicity. Salarius expects to release early cohort data early next year from its Ewing sarcoma study and a second Phase 1 clinical study in advanced solid tumors, including prostate, breast and ovarian cancers. A preclinical program in glioblastoma is underway at the Barrow Neurological Institute ‘s Ivy Brain Tumor Center.
More information about Salarius’ ongoing Ewing sarcoma trial is available at ClinicalTrials.gov and on the company website, salariuspharma.com. Active clinical trial sites include, Memorial Sloan Kettering Cancer Center in New York City, Nationwide Children’s Hospital in Columbus, OH, Johns Hopkins All Children’s Hospital in St. Petersburg, FL; Children’s Hospital of Los Angeles in Los Angeles, CA; Moffitt Cancer Center in Tampa, FL; Dana-Farber Cancer Institute in Boston, MA; MD Anderson Cancer Center in Houston, TX; and the Sarcoma Oncology Center in Santa Monica, CA.
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this press release are forward-looking statements. These forward-looking statements may be identified by terms such as “will,” “can,”” “could,” “believe,” “feel,” “plan,” “allow,” “will,” “expect,” “provide,” “able to,” “position,” “anticipate,” “progress,” “potential,” “target,” and similar terms or expressions or the negative thereof. Examples of such statements include, but are not limited to, statements regarding: Dr. Sharma’s research representing a significant potential advancement for the company and Seclidemstat as it demonstrates the potential for the drug to be utilized in combination with checkpoint inhibitors in the treatment of a readily identifiable patient population with specific mutations; the company’s plans to explore the use of Seclidemstat in multiple indications, and the potential opportunity to combine the company’s LSD1 inhibitor with checkpoint inhibitors and develop cancer treatments for patients who need them most; anticipated milestones from the company’s clinical development pipeline, which is led by Seclidemstat; the ongoing Seclidemstat Phase 1/2 clinical trial; the study of Seclidemstat in a second Phase 1 clinical trial in advanced solid tumors; the company’s plans to release early cohort data and expected timing thereof; the company’s belief that Seclidemstat is one of only two reversible inhibitors of the epigenetic modulator LSD1 currently in human trials, and that it could have potential for improved safety and efficacy compared to other LSD1-targeted therapies, more flexible dosing and less toxicity; and the company’s development of Seclidemstat for several cancers with high unmet medical need, with a second Phase 1 clinical study in advanced solid tumors, including prostate, breast and ovarian cancers. Salarius may not actually achieve the plans, carry out the intentions or meet the expectations or objectives disclosed in the forward-looking statements. You should not place undue reliance on these forward-looking statements. These statements are subject to risks and uncertainties which could cause actual results and performance to differ materially from those discussed in the forward-looking statements. These risks and uncertainties include, but are not limited to, the following: the ability of the company to raise additional capital to meet the company’s business operational needs and to achieve its business objectives and strategy; the company’s ability to project future capital needs and cash utilization; available sources of cash, including from CPRIT and its equity line; future clinical trial results; that the results of studies and clinical trials may not be predictive of future clinical trial results; the sufficiency of Salarius’ intellectual property protection; risks related to the drug development and the regulatory approval process; the competitive landscape and other industry-related risks; market conditions which may impact the ability of Salarius access capital under its equity line; the possibility of unexpected expenses or other uses of Salarius’ cash resources; and other risks described in Salarius’ filings with the Securities and Exchange Commission, including those under the heading “Risk Factors.” The forward-looking statements contained in this press release speak only as of the date of this press release and are based on management’s assumptions and estimates as of such date. Salarius disclaims any intent or obligation to update these forward-looking statements to reflect events or circumstances that exist after the date on which they were made
Senior Vice President
Source: Salarius Pharmaceuticals